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BRCA1 is an essential regulator of heart function and survival following myocardial infarction
The tumour suppressor BRCA1 is mutated in familial breast and ovarian cancer but its role in protecting other tissues from DNA damage has not been explored. Here we show a new role for BRCA1 as a gatekeeper of cardiac function and survival. In mice, loss of BRCA1 in cardiomyocytes results in adverse...
Autores principales: | Shukla, Praphulla C., Singh, Krishna K., Quan, Adrian, Al-Omran, Mohammed, Teoh, Hwee, Lovren, Fina, Cao, Liu, Rovira, Ilsa I., Pan, Yi, Brezden-Masley, Christine, Yanagawa, Bobby, Gupta, Aanika, Deng, Chu-Xia, Coles, John G., Leong-Poi, Howard, Stanford, William L., Parker, Thomas G., Schneider, Michael D., Finkel, Toren, Verma, Subodh |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247816/ https://www.ncbi.nlm.nih.gov/pubmed/22186889 http://dx.doi.org/10.1038/ncomms1601 |
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