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Notch1 binds and induces degradation of Snail in hepatocellular carcinoma

BACKGROUND: Hepatocellular carcinoma (HCC) is a common, highly invasive malignant tumor associated with a high mortality rate. We previously reported that the aberrant expression of Snail via activation of reactive oxygen species contributes to the invasive property of HCC, in part by downregulation...

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Detalles Bibliográficos
Autores principales: Lim, Seung-Oe, Kim, Hyeon Seop, Quan, Xiaoyuan, Ahn, Sun-Min, Kim, Hongtae, Hsieh, David, Seong, Je Kyung, Jung, Guhung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247845/
https://www.ncbi.nlm.nih.gov/pubmed/22128911
http://dx.doi.org/10.1186/1741-7007-9-83