Novel Insights into the Molecular Mechanisms Governing Mdm2 Ubiquitination and Destruction

The Mdm2/p53 pathway is compromised in more than 50% of all human cancers, therefore it is an intensive area of research to understand the upstream regulatory pathways governing Mdm2/p53 activity. Mdm2 is frequently overexpressed in human cancers while the molecular mechanisms underlying the timely...

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Detalles Bibliográficos
Autores principales: Inuzuka, Hiroyuki, Fukushima, Hidefumi, Shaik, Shavali, Wei, Wenyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2010
Materias:
Research Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248122/
https://www.ncbi.nlm.nih.gov/pubmed/21317463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248122/
https://www.ncbi.nlm.nih.gov/pubmed/21317463

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