Exogenous IFN-alpha Administration Reduces Influenza A Virus Replication in the Lower Respiratory Tract of Rhesus Macaques

To determine the role of innate immune responses in controlling influenza A virus replication, rhesus macaques (RM) were administered pegylated IFN-alpha prior to virus challenge. Systemic and mucosal pegylated IFN-alpha administration induced expression of the interferon-stimulated genes (ISG) MxA...

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Detalles Bibliográficos
Autores principales: Matzinger, Shannon R., Carroll, Timothy D., Fritts, Linda, McChesney, Michael B., Miller, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248419/
https://www.ncbi.nlm.nih.gov/pubmed/22220209
http://dx.doi.org/10.1371/journal.pone.0029255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248419/
https://www.ncbi.nlm.nih.gov/pubmed/22220209
http://dx.doi.org/10.1371/journal.pone.0029255

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