A Genetic Screening Strategy Identifies Novel Regulators of the Proteostasis Network

A hallmark of diseases of protein conformation and aging is the appearance of protein aggregates associated with cellular toxicity. We posit that the functional properties of the proteostasis network (PN) protect the proteome from misfolding and combat the proteotoxic events leading to cellular path...

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Detalles Bibliográficos
Autores principales: Silva, M. Catarina, Fox, Susan, Beam, Monica, Thakkar, Happy, Amaral, Margarida D., Morimoto, Richard I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248563/
https://www.ncbi.nlm.nih.gov/pubmed/22242008
http://dx.doi.org/10.1371/journal.pgen.1002438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248563/
https://www.ncbi.nlm.nih.gov/pubmed/22242008
http://dx.doi.org/10.1371/journal.pgen.1002438

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