Decoding cell lineage from acquired mutations using arbitrary deep sequencing

Because mutations are inevitable, the genome of each cell in a multicellular organism becomes unique and therefore encodes a record of its ancestry. Here we couple arbitrary single primer PCR with “next generation” DNA sequencing in order to catalog mutations and deconvolve the phylogeny of cultured...

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Detalles Bibliográficos
Autores principales: Carlson, Cheryl A, Kas, Arnold, Kirkwood, Robert, Hays, Laura E, Preston, Bradley D, Salipante, Stephen J, Horwitz, Marshall S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248619/
https://www.ncbi.nlm.nih.gov/pubmed/22120468
http://dx.doi.org/10.1038/nmeth.1781

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248619/
https://www.ncbi.nlm.nih.gov/pubmed/22120468
http://dx.doi.org/10.1038/nmeth.1781

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