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Decoding cell lineage from acquired mutations using arbitrary deep sequencing
Because mutations are inevitable, the genome of each cell in a multicellular organism becomes unique and therefore encodes a record of its ancestry. Here we couple arbitrary single primer PCR with “next generation” DNA sequencing in order to catalog mutations and deconvolve the phylogeny of cultured...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248619/ https://www.ncbi.nlm.nih.gov/pubmed/22120468 http://dx.doi.org/10.1038/nmeth.1781 |