Rapid degradation of cyclooxygenase-1 and hematopoietic prostaglandin D synthase through ubiquitin–proteasome system in response to intracellular calcium level

Cyclooxygenase (COX)-1 and hematopoietic prostaglandin (PG) D synthase (H-PGDS) proteins, which are both involved in the arachidonate cascade, were stable in human megakaryocytic MEG-01 cells. In contrast, once the intracellular calcium level was increased by treatment with a calcium ionophore, both...

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Detalles Bibliográficos
Autores principales: Yazaki, Misato, Kashiwagi, Kaori, Aritake, Kosuke, Urade, Yoshihiro, Fujimori, Ko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248891/
https://www.ncbi.nlm.nih.gov/pubmed/22049022
http://dx.doi.org/10.1091/mbc.E11-07-0623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248891/
https://www.ncbi.nlm.nih.gov/pubmed/22049022
http://dx.doi.org/10.1091/mbc.E11-07-0623

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