The relationship between clinical pharmacokinetics of aripiprazole and CYP2D6 genetic polymorphism: effects of CYP enzyme inhibition by coadministration of paroxetine or fluvoxamine

PURPOSE: To investigate the effects of coadministration of paroxetine or fluvoxamine on the pharmacokinetics of aripiprazole in healthy adult Japanese with different CYP2D6 genotypes. METHODS: Fourteen CYP2D6 extensive metabolizer (EM) and 14 CYP2D6 intermediate metabolizer (IM) subjects were coadmi...

Descripción completa

Detalles Bibliográficos
Autores principales: Azuma, Junichi, Hasunuma, Tomoko, Kubo, Masanori, Miyatake, Masaya, Koue, Toshiko, Higashi, Koushi, Fujiwara, Tsutomu, Kitahara, Sachiko, Katano, Tamiki, Hara, Sumiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Clinical Trial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249179/
https://www.ncbi.nlm.nih.gov/pubmed/21739267
http://dx.doi.org/10.1007/s00228-011-1094-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249179/
https://www.ncbi.nlm.nih.gov/pubmed/21739267
http://dx.doi.org/10.1007/s00228-011-1094-4

Ejemplares similares