Optimal dose finding of garenoxacin based on population pharmacokinetics/pharmacodynamics and Monte Carlo simulation

PURPOSE: Garenoxacin, a novel des-F(6)-quinolone, possesses potent antibacterial activity against infectious pathogens in the respiratory tract. Population pharmacokinetic/pharmacodynamic (PK/PD) modeling and Monte Carlo simulations were used to optimize garenoxacin dosage regimens. METHODS: At the...

Descripción completa

Detalles Bibliográficos
Autores principales: Tanigawara, Yusuke, Nozawa, Kenji, Tsuda, Hisatsugu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Pharmacodynamics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249185/
https://www.ncbi.nlm.nih.gov/pubmed/21796376
http://dx.doi.org/10.1007/s00228-011-1095-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249185/
https://www.ncbi.nlm.nih.gov/pubmed/21796376
http://dx.doi.org/10.1007/s00228-011-1095-3

Ejemplares similares