Metformin and the ATM DNA damage response (DDR): Accelerating the onset of stress-induced senescence to boost protection against cancer

By activating the ataxia telangiectasia mutated (ATM)-mediated DNA Damage Response (DDR), the AMPK agonist metformin might sensitize cells against further damage, thus mimicking the precancerous stimulus that induces an intrinsic barrier against carcinogenesis. Herein, we present the new hypothesis...

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Detalles Bibliográficos
Autores principales: Menendez, Javier A., Cufí, Sílvia, Oliveras-Ferraros, Cristina, Martin-Castillo, Begoña, Joven, Jorge, Vellon, Luciano, Vazquez-Martin, Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2011
Materias:
Research Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249452/
https://www.ncbi.nlm.nih.gov/pubmed/22170748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249452/
https://www.ncbi.nlm.nih.gov/pubmed/22170748

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