Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome

Over-inhibition is thought to be one of the underlying causes of the cognitive deficits in Ts65Dn mice, the most widely used model of Down syndrome (DS). Here we demonstrate a direct link between gene triplication and defects in neuron production during embryonic development. These neurogenesis defe...

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Detalles Bibliográficos
Autores principales: Chakrabarti, Lina, Best, Tyler K., Cramer, Nathan P., Carney, Rosalind S.E., Isaac, John T.R., Galdzicki, Zygmunt, Haydar, Tarik F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249618/
https://www.ncbi.nlm.nih.gov/pubmed/20639873
http://dx.doi.org/10.1038/nn.2600

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249618/
https://www.ncbi.nlm.nih.gov/pubmed/20639873
http://dx.doi.org/10.1038/nn.2600

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