Protective effects of goldenseal (Hydrastis canadensis L.) on acetaminophen-induced hepatotoxicity through inhibition of CYP2E1 in rats

BACKGROUND: Goldenseal (Hydrastis canadensis L.) inhibits various cytochrome P450 (CYP) isoforms such as CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A in vitro. High doses of acetaminophen (APAP) generate the highly reactive intermediate, N-acetyl-p-benzoquinone imine (NAPQI), catalyzed mainly by CYP2E...

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Detalles Bibliográficos
Autores principales: Yamaura, Katsunori, Shimada, Maki, Nakayama, Noriyuki, Ueno, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249784/
https://www.ncbi.nlm.nih.gov/pubmed/22224048
http://dx.doi.org/10.4103/0974-8490.89745

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249784/
https://www.ncbi.nlm.nih.gov/pubmed/22224048
http://dx.doi.org/10.4103/0974-8490.89745

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