Cargando…

Protective effects of goldenseal (Hydrastis canadensis L.) on acetaminophen-induced hepatotoxicity through inhibition of CYP2E1 in rats

BACKGROUND: Goldenseal (Hydrastis canadensis L.) inhibits various cytochrome P450 (CYP) isoforms such as CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A in vitro. High doses of acetaminophen (APAP) generate the highly reactive intermediate, N-acetyl-p-benzoquinone imine (NAPQI), catalyzed mainly by CYP2E...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yamaura, Katsunori, Shimada, Maki, Nakayama, Noriyuki, Ueno, Koichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Medknow Publications & Media Pvt Ltd 2011
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249784/ https://www.ncbi.nlm.nih.gov/pubmed/22224048 http://dx.doi.org/10.4103/0974-8490.89745

Ejemplares similares

Protective effects of natsumikan (Citrus natsudaidai) extract on acetaminophen-induced lethal hepatotoxicity in mice
por: Yamaura, Katsunori, et al.
Publicado: (2012)

Hydrastis Canadensis
Publicado: (1891)

Hydrastis Canadensis
por: McNeil, A.
Publicado: (1889)

On the Alkaloids of Hydrastis Canadensis
por: Merrill, Wm. S.
Publicado: (1862)

Hydrastis Canadensis in Uterine Troubles
por: Barron, Robt. B.
Publicado: (1888)

Contribution to the Study of Hydrastis Canadensis
Publicado: (1888)

Hydrastis Canadensis in the Treatment of Bronchial Catarrh
Publicado: (1897)

Hydrastis Canadensis in Uterine Hemorrhage, and Menorrhagia; and Also in Dysmenorrhea
por: Gordon, W. A.
Publicado: (1877)

Hydrastis Canadensis in Uterine Hæmorrhage, and Menorrhagia ; and Also in Dysmenorrhea
por: Gordon, W. A.
Publicado: (1877)

In Silico Analysis of the Effect of Hydrastis canadensis on Controlling Breast Cancer
por: Vyshnavi AM, Hima, et al.
Publicado: (2023)

Extract from peel of Citrus natsudaidai alleviates experimental chronic allergic dermatitis in mice
por: Nakayama, Noriyuki, et al.
Publicado: (2011)

Antidepressant-like effects of young green barley leaf (Hordeum vulgare L.) in the mouse forced swimming test
por: Yamaura, Katsunori, et al.
Publicado: (2012)

Anthocyanins from bilberry (Vaccinium myrtillus L.) alleviate pruritus in a mouse model of chronic allergic contact dermatitis
por: Yamaura, Katsunori, et al.
Publicado: (2011)

Mechanism study of goldenseal-associated DNA damage
por: Chen, Si, et al.
Publicado: (2013)

Effects of Dietary Inclusion of Dry Hydrastis canadensis on Laying Performance, Egg Quality, Serum Biochemical Parameters and Cecal Microbiota in Laying Hens
por: Tzeng, Tzuen-Rong J, et al.
Publicado: (2021)

Chitohexaose protects against acetaminophen-induced hepatotoxicity in mice
por: Barman, P K, et al.
Publicado: (2016)

Calcitriol Protects against Acetaminophen-Induced Hepatotoxicity in Mice
por: Sriphoosanaphan, Supachaya, et al.
Publicado: (2023)

Protective Effects of Apamin on Acetaminophen-Induced Hepatotoxicity in Mice
por: Jang, Hyo-Jeong, et al.
Publicado: (2023)

Gut Commensal Fungi Protect Against Acetaminophen-Induced Hepatotoxicity by Reducing Cyp2a5 Expression in Mice
por: He, Zhuoen, et al.
Publicado: (2022)

Impact of malnourishment on the pharmacokinetics of acetaminophen and susceptibility to acetaminophen hepatotoxicity
por: Zillen, Daan, et al.
Publicado: (2021)

Evaluation of the Protective Effects of Doxycycline on Acetaminophen-Induced Hepatotoxicity in Mice
por: Soltani, Shirin, et al.
Publicado: (2019)

Goldenseal-Mediated Inhibition of Intestinal Uptake Transporters Decreases Metformin Systemic Exposure in Mice
por: Oyanna, Victoria O., et al.
Publicado: (2023)

Mitochondrial–Lysosomal Axis in Acetaminophen Hepatotoxicity
por: Moles, Anna, et al.
Publicado: (2018)

Role of Pyroptosis in Acetaminophen-Induced Hepatotoxicity
por: Jaeschke, Hartmut, et al.
Publicado: (2022)

Regeneration and Recovery after Acetaminophen Hepatotoxicity
por: Bhushan, Bharat, et al.
Publicado: (2023)

Study of the Protective Effect of Teucrium polium L. Extract on Acetaminophen-Induced Hepatotoxicity in Mice
por: Forouzandeh, Hossein, et al.
Publicado: (2013)

Acetaminophen Hepatotoxicity: Not as Simple as One Might Think! Introductory Comments on the Special Issue—Recent Advances in Acetaminophen Hepatotoxicity
por: Jaeschke, Hartmut
Publicado: (2022)

CYP2E1 inhibition and NF_κB Signaling Pathway are Involved in the Protective Molecular Effect of Origanum floribundum against Acetaminophen-induced acute Hepatotoxicity in Rats
por: Khelfallah, Amina, et al.
Publicado: (2021)

Chemical Evaluation of the Effects of Storage Conditions on the Botanical Goldenseal using Marker-based and Metabolomics Approaches
por: Khin, Manead, et al.
Publicado: (2020)

Autophagy Protects against CYP2E1/Chronic Ethanol-Induced Hepatotoxicity
por: Lu, Yongke, et al.
Publicado: (2015)

IRE1α activation protects mice against acetaminophen-induced hepatotoxicity
por: Hur, Kyu Yeon, et al.
Publicado: (2012)

Attenuating Oxidative Stress by Paeonol Protected against Acetaminophen-Induced Hepatotoxicity in Mice
por: Ding, Yi, et al.
Publicado: (2016)

Protective Effects of Interleukin-37 Expression against Acetaminophen-Induced Hepatotoxicity in Mice
por: Xu, Zhiwei, et al.
Publicado: (2022)

Silymarin prevents acetaminophen-induced hepatotoxicity in mice
por: Papackova, Zuzana, et al.
Publicado: (2018)

Characteristics and Outcomes of Acetaminophen Overdose and Hepatotoxicity in Thailand
por: Pholmoo, Natthiya, et al.
Publicado: (2019)

Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology
por: Ramachandran, Anup, et al.
Publicado: (2017)

Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update
por: Yoon, Eric, et al.
Publicado: (2016)

Possible Role of Extracellular Vesicles in Hepatotoxicity of Acetaminophen
por: Šrajer Gajdošik, Martina, et al.
Publicado: (2022)

Fluorine-thiol displacement probes for acetaminophen's hepatotoxicity
por: Prather, Benjamin L., et al.
Publicado: (2023)

Protective Effect of Gemfibrozil on Hepatotoxicity Induced by Acetaminophen in Mice: the Importance of Oxidative Stress Suppression
por: Nikravesh, Hojatolla, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_58nv21bimfcg9l34s7bl1qgg8g