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Identification of the protease inhibitor miraziridine A in the Red sea sponge Theonella swinhoei

BACKGROUND: Miraziridine A, a natural peptide isolated from a marine sponge, is a potent cathepsin B inhibitor with a second-order rate constant of 1.5 × 10(4) M(-1) s(-1). In the present study, miraziridine A was isolated from the Red Sea sponge Theonella swinhoei on the basis of chromatographic an...

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Detalles Bibliográficos
Autores principales: Tabares, Paula, Degel, Björn, Schaschke, Norbert, Hentschel, Ute, Schirmeister, Tanja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250042/
https://www.ncbi.nlm.nih.gov/pubmed/22224064
http://dx.doi.org/10.4103/0974-8490.91047