Intra- and Inter-Tumor Heterogeneity of BRAF(V600E)Mutations in Primary and Metastatic Melanoma

The rationale for using small molecule inhibitors of oncogenic proteins as cancer therapies depends, at least in part, on the assumption that metastatic tumors are primarily clonal with respect to mutant oncogene. With the emergence of BRAF(V600E) as a therapeutic target, we investigated intra- and...

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Detalles Bibliográficos
Autores principales: Yancovitz, Molly, Litterman, Adam, Yoon, Joanne, Ng, Elise, Shapiro, Richard L., Berman, Russell S., Pavlick, Anna C., Darvishian, Farbod, Christos, Paul, Mazumdar, Madhu, Osman, Iman, Polsky, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250426/
https://www.ncbi.nlm.nih.gov/pubmed/22235286
http://dx.doi.org/10.1371/journal.pone.0029336

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250426/
https://www.ncbi.nlm.nih.gov/pubmed/22235286
http://dx.doi.org/10.1371/journal.pone.0029336

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