CUGBP1 and MBNL1 preferentially bind to 3′ UTRs and facilitate mRNA decay

CUGBP1 and MBNL1 are developmentally regulated RNA-binding proteins that are causally associated with myotonic dystrophy type 1. We globally determined the in vivo RNA-binding sites of CUGBP1 and MBNL1. Interestingly, CUGBP1 and MBNL1 are both preferentially bound to 3′ UTRs. Analysis of CUGBP1- and...

Descripción completa

Detalles Bibliográficos
Autores principales: Masuda, Akio, Andersen, Henriette Skovgaard, Doktor, Thomas Koed, Okamoto, Takaaki, Ito, Mikako, Andresen, Brage Storstein, Ohno, Kinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250574/
https://www.ncbi.nlm.nih.gov/pubmed/22355723
http://dx.doi.org/10.1038/srep00209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250574/
https://www.ncbi.nlm.nih.gov/pubmed/22355723
http://dx.doi.org/10.1038/srep00209

Ejemplares similares