P-glycoprotein at the blood-brain barrier: kinetic modeling of (11)C-desmethylloperamide in mice using a (18)F-FDG μPET scan to determine the input function

PURPOSE: The objective of this study is the implementation of a kinetic model for (11)C-desmethylloperamide ((11)C-dLop) and the determination of a typical parameter for P-glycoprotein (P-gp) functionality in mice. Since arterial blood sampling in mice is difficult, an alternative method to obtain t...

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Detalles Bibliográficos
Autores principales: Moerman, Lieselotte, De Naeyer, Dieter, Boon, Paul, De Vos, Filip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2011
Materias:
Preliminary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250994/
https://www.ncbi.nlm.nih.gov/pubmed/22214199
http://dx.doi.org/10.1186/2191-219X-1-12

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250994/
https://www.ncbi.nlm.nih.gov/pubmed/22214199
http://dx.doi.org/10.1186/2191-219X-1-12

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