TLR9 Agonist Protects Mice from Radiation-Induced Gastrointestinal Syndrome

PURPOSE: Radiation-induced gastrointestinal syndrome (RIGS) is due to the clonogenic loss of crypt cells and villi depopulation, resulting in disruption of mucosal barrier, bacterial invasion, inflammation and sepsis. Intestinal macrophages could recognize invading bacterial DNA via TLR9 receptors a...

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Detalles Bibliográficos
Autores principales: Saha, Subhrajit, Bhanja, Payel, Liu, Laibin, Alfieri, Alan A., Yu, Dong, Kandimalla, Ekambar R., Agrawal, Sudhir, Guha, Chandan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251576/
https://www.ncbi.nlm.nih.gov/pubmed/22238604
http://dx.doi.org/10.1371/journal.pone.0029357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251576/
https://www.ncbi.nlm.nih.gov/pubmed/22238604
http://dx.doi.org/10.1371/journal.pone.0029357

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