An Osteoblast-Derived Proteinase Controls Tumor Cell Survival via TGF-beta Activation in the Bone Microenvironment

BACKGROUND: Breast to bone metastases frequently induce a “vicious cycle” in which osteoclast mediated bone resorption and proteolysis results in the release of bone matrix sequestered factors that drive tumor growth. While osteoclasts express numerous proteinases, analysis of human breast to bone m...

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Detalles Bibliográficos
Autores principales: Thiolloy, Sophie, Edwards, James R., Fingleton, Barbara, Rifkin, Daniel B., Matrisian, Lynn M., Lynch, Conor C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251607/
https://www.ncbi.nlm.nih.gov/pubmed/22238668
http://dx.doi.org/10.1371/journal.pone.0029862

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251607/
https://www.ncbi.nlm.nih.gov/pubmed/22238668
http://dx.doi.org/10.1371/journal.pone.0029862

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