Cargando…

An Osteoblast-Derived Proteinase Controls Tumor Cell Survival via TGF-beta Activation in the Bone Microenvironment

BACKGROUND: Breast to bone metastases frequently induce a “vicious cycle” in which osteoclast mediated bone resorption and proteolysis results in the release of bone matrix sequestered factors that drive tumor growth. While osteoclasts express numerous proteinases, analysis of human breast to bone m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thiolloy, Sophie, Edwards, James R., Fingleton, Barbara, Rifkin, Daniel B., Matrisian, Lynn M., Lynch, Conor C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251607/ https://www.ncbi.nlm.nih.gov/pubmed/22238668 http://dx.doi.org/10.1371/journal.pone.0029862

Ejemplares similares

Cleavage of E-Cadherin by Matrix Metalloproteinase-7 Promotes Cellular Proliferation in Nontransformed Cell Lines via Activation of RhoA
por: Lynch, Conor C., et al.
Publicado: (2010)

Osteoblasts Are the Centerpiece of the Metastatic Bone Microenvironment
por: Jeong, Hyo Min, et al.
Publicado: (2016)

Osteoblasts synthesize and respond to transforming growth factor-type beta (TGF-beta) in vitro
Publicado: (1987)

Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype
Publicado: (1996)

Influence of the TGF-β Superfamily on Osteoclasts/Osteoblasts Balance in Physiological and Pathological Bone Conditions
por: Jann, Jessica, et al.
Publicado: (2020)

TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation
por: Chen, Guiqian, et al.
Publicado: (2012)

Pulsed Electromagnetic Field Regulates MicroRNA 21 Expression to Activate TGF-β Signaling in Human Bone Marrow Stromal Cells to Enhance Osteoblast Differentiation
por: Selvamurugan, Nagarajan, et al.
Publicado: (2017)

NFAT Signaling in Osteoblasts Regulates the Hematopoietic Niche in the Bone Microenvironment
por: Sesler, Cheryl L., et al.
Publicado: (2013)

Cabozantinib targets bone microenvironment modulating human osteoclast and osteoblast functions
por: Fioramonti, Marco, et al.
Publicado: (2017)

‘Educated’ Osteoblasts Reduce Osteoclastogenesis in a Bone-Tumor Mimetic Microenvironment
por: Kolb, Alexus D., et al.
Publicado: (2021)

TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease
por: Wu, Mengrui, et al.
Publicado: (2016)

Osteoblasts are “educated” by crosstalk with metastatic breast cancer cells in the bone tumor microenvironment
por: Kolb, Alexus D., et al.
Publicado: (2019)

Substrate Stiffness of Bone Microenvironment Controls Functions of Pre-Osteoblasts and Fibroblasts In Vitro
por: Gao, Shenghan, et al.
Publicado: (2023)

TGF-beta1 on osteoimmunology and the bone component cells
por: Kasagi, Shimpei, et al.
Publicado: (2013)

TGF-Beta Signaling in Bone with Chronic Kidney Disease
por: Iwasaki, Yoshiko, et al.
Publicado: (2018)

Cells derived from murine induced pluripotent stem cells (iPSC) by treatment with members of TGF-beta family give rise to osteoblasts differentiation and form bone in vivo
por: Li, Feng, et al.
Publicado: (2012)

Proteinases in the joint: clinical relevance of proteinases in joint destruction
por: Rengel, Yvonne, et al.
Publicado: (2007)

Pest Protection Conferred by a Beta vulgaris Serine Proteinase Inhibitor Gene
por: Smigocki, Ann C., et al.
Publicado: (2013)

Proteinase-Activated Receptor 2 Is a Novel Regulator of TGF-β Signaling in Pancreatic Cancer
por: Witte, David, et al.
Publicado: (2016)

Proteinase-Activated Receptor 2 May Drive Cancer Progression by Facilitating TGF-β Signaling
por: Ungefroren, Hendrik, et al.
Publicado: (2017)

Expression of transforming growth factor beta (TGF beta) receptors and expression of TGF beta 1, TGF beta 2 and TGF beta 3 in human small cell lung cancer cell lines.
por: Damstrup, L., et al.
Publicado: (1993)

The Host Microenvironment Influences Prostate Cancer Invasion, Systemic Spread, Bone Colonization, and Osteoblastic Metastasis
por: Ganguly, Sourik S., et al.
Publicado: (2014)

Novel bone microenvironment model of castration-resistant prostate cancer with chitosan fiber matrix and osteoblasts
por: Samoto, Masahiro, et al.
Publicado: (2021)

Arhgap21 Deficiency Results in Increase of Osteoblastic Lineage Cells in the Murine Bone Marrow Microenvironment
por: Pissarra, Mariana Ferreira, et al.
Publicado: (2021)

Effects of Beta-Blockers on Melanoma Microenvironment and Disease Survival in Human
por: Wrobel, Ludovic Jean, et al.
Publicado: (2020)

Proteinases and Tumour Invasion
por: Schor, S.
Publicado: (1982)

Viral cysteine proteinases
por: Gorbalenya, Alexander E., et al.
Publicado: (1996)

PROTEINASE INHIBITORS | Cystatins
por: Pemberton, P.A.
Publicado: (2006)

Selective inhibition of matrix metalloproteinase-2 in the multiple myeloma-bone microenvironment
por: Shay, Gemma, et al.
Publicado: (2017)

Engineering osteoblastic metastases to delineate the adaptive response of androgen-deprived prostate cancer in the bone metastatic microenvironment
por: Bock, Nathalie, et al.
Publicado: (2019)

Osteoblast Interactions Within a Biomimetic Apatite Microenvironment
por: Tsang, Eric J., et al.
Publicado: (2011)

Relationship of proteinases and proteinase inhibitors with microbial presence in chronic lung disease of prematurity
por: Davies, Philip L, et al.
Publicado: (2010)

TGF-beta expression during rat pregnancy and activity on decidual cell survival
por: Shooner, Carl, et al.
Publicado: (2005)

The innate immune response, microenvironment proteinases, and the COVID-19 pandemic: pathophysiologic mechanisms and emerging therapeutic targets
por: Hollenberg, Morley D., et al.
Publicado: (2022)

Metabolism in the Tumour-Bone Microenvironment
por: Whitburn, Jessica, et al.
Publicado: (2021)

Bone abnormalities in latent TGF-β binding protein (Ltbp)-3–null mice indicate a role for Ltbp-3 in modulating TGF-β bioavailability
por: Dabovic, Branka, et al.
Publicado: (2002)

The Effects of TGF-β Signaling on Cancer Cells and Cancer Stem Cells in the Bone Microenvironment
por: Futakuchi, Mitsuru, et al.
Publicado: (2019)

Expression and partial purification of recombinant tomato ringspot nepovirus 3C-like proteinase: comparison of the activity of the mature proteinase and the VPg-proteinase precursor
por: Chisholm, Joan, et al.
Publicado: (2001)

Skeletal microenvironment system utilising bovine bone scaffold co-cultured with human osteoblasts and osteoclast-like cells
por: Jolly, James Jam, et al.
Publicado: (2021)

The role of osteoblasts in bone metastasis
por: Ottewell, Penelope D
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_aljqidjbk0r36oqvv5lqekj67h