High basal NF-κB activity in nonpigmented melanoma cells is associated with an enhanced sensitivity to vitamin D3 derivatives

BACKGROUND: Melanoma is highly resistant to current modalities of therapy, with the extent of pigmentation playing an important role in therapeutic resistance. Nuclear factor-κB (NF-κB) is constitutively activated in melanoma and can serve as a molecular target for cancer therapy and steroid/secoste...

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Detalles Bibliográficos
Autores principales: Janjetovic, Z, Brozyna, A A, Tuckey, R C, Kim, T-K, Nguyen, M N, Jozwicki, W, Pfeffer, S R, Pfeffer, L M, Slominski, A T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251881/
https://www.ncbi.nlm.nih.gov/pubmed/22095230
http://dx.doi.org/10.1038/bjc.2011.458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251881/
https://www.ncbi.nlm.nih.gov/pubmed/22095230
http://dx.doi.org/10.1038/bjc.2011.458

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