A Viral Dynamic Model for Treatment Regimens with Direct-acting Antivirals for Chronic Hepatitis C Infection

We propose an integrative, mechanistic model that integrates in vitro virology data, pharmacokinetics, and viral response to a combination regimen of a direct-acting antiviral (telaprevir, an HCV NS3-4A protease inhibitor) and peginterferon alfa-2a/ribavirin (PR) in patients with genotype 1 chronic...

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Detalles Bibliográficos
Autores principales: Adiwijaya, Bambang S., Kieffer, Tara L., Henshaw, Joshua, Eisenhauer, Karen, Kimko, Holly, Alam, John J., Kauffman, Robert S., Garg, Varun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252270/
https://www.ncbi.nlm.nih.gov/pubmed/22241977
http://dx.doi.org/10.1371/journal.pcbi.1002339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252270/
https://www.ncbi.nlm.nih.gov/pubmed/22241977
http://dx.doi.org/10.1371/journal.pcbi.1002339

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