Impedance Responses Reveal β(2)-Adrenergic Receptor Signaling Pluridimensionality and Allow Classification of Ligands with Distinct Signaling Profiles

The discovery that drugs targeting a single G protein-coupled receptor (GPCR) can differentially modulate distinct subsets of the receptor signaling repertoire has created a challenge for drug discovery at these important therapeutic targets. Here, we demonstrate that a single label-free assay based...

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Detalles Bibliográficos
Autores principales: Stallaert, Wayne, Dorn, Jonas F., van der Westhuizen, Emma, Audet, Martin, Bouvier, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252315/
https://www.ncbi.nlm.nih.gov/pubmed/22242170
http://dx.doi.org/10.1371/journal.pone.0029420

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252315/
https://www.ncbi.nlm.nih.gov/pubmed/22242170
http://dx.doi.org/10.1371/journal.pone.0029420

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