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Construction of permanently inducible miRNA-based expression vectors using site-specific recombinases

BACKGROUND: RNA interference (RNAi) is a conserved gene silencing mechanism mediated by small inhibitory microRNAs (miRNAs). Promoter-driven miRNA expression vectors have emerged as important tools for delivering natural or artificially designed miRNAs to eukaryotic cells and organisms. Such systems...

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Detalles Bibliográficos
Autores principales: Garwick-Coppens, Sara E, Herman, Adam, Harper, Scott Q
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252340/
https://www.ncbi.nlm.nih.gov/pubmed/22087765
http://dx.doi.org/10.1186/1472-6750-11-107