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1,25-Dihydroxyvitamin D3 Treatment Delays Cellular Aging in Human Mesenchymal Stem Cells while Maintaining Their Multipotent Capacity

1,25-dihydroxyvitamin D3 (1,25D3) was reported to induce premature organismal aging in fibroblast growth factor-23 (Fgf23) and klotho deficient mice, which is of main interest as 1,25D3 supplementation of its precursor cholecalciferol is used in basic osteoporosis treatment. We wanted to know if 1,2...

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Detalles Bibliográficos
Autores principales: Klotz, Barbara, Mentrup, Birgit, Regensburger, Martina, Zeck, Sabine, Schneidereit, Jutta, Schupp, Nicole, Linden, Christian, Merz, Cornelia, Ebert, Regina, Jakob, Franz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252365/
https://www.ncbi.nlm.nih.gov/pubmed/22242193
http://dx.doi.org/10.1371/journal.pone.0029959