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SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism
Genetic mutations of SHANK3 have been reported in patients with intellectual disability, autism spectrum disorder (ASD) and schizophrenia. At the synapse, Shank3/ProSAP2 is a scaffolding protein that connects glutamate receptors to the actin cytoskeleton via a chain of intermediary elements. Althoug...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252613/ https://www.ncbi.nlm.nih.gov/pubmed/21606927 http://dx.doi.org/10.1038/mp.2011.57 |