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SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism

Genetic mutations of SHANK3 have been reported in patients with intellectual disability, autism spectrum disorder (ASD) and schizophrenia. At the synapse, Shank3/ProSAP2 is a scaffolding protein that connects glutamate receptors to the actin cytoskeleton via a chain of intermediary elements. Althoug...

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Detalles Bibliográficos
Autores principales: Durand, C M, Perroy, J, Loll, F, Perrais, D, Fagni, L, Bourgeron, T, Montcouquiol, M, Sans, N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252613/
https://www.ncbi.nlm.nih.gov/pubmed/21606927
http://dx.doi.org/10.1038/mp.2011.57