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Tertiary alcohol preferred: Hydroxylation of trans-3-methyl-L-proline with proline hydroxylases

The enzymatic synthesis of tertiary alcohols by the stereospecific oxidation of tertiary alkyl centers is a most-straightforward but challenging approach, since these positions are sterically hindered. In contrast to P450-monooxygenases, there is little known about the potential of non-heme iron(II)...

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Detalles Bibliográficos
Autores principales: Klein, Christian, Hüttel, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252868/
https://www.ncbi.nlm.nih.gov/pubmed/22238542
http://dx.doi.org/10.3762/bjoc.7.193