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Synthesis of 2-amino-3-arylpropan-1-ols and 1-(2,3-diaminopropyl)-1,2,3-triazoles and evaluation of their antimalarial activity

A variety of 2-amino-3-arylpropan-1-ols, anti-2-amino-3-aryl-3-methoxypropan-1-ols and anti-2-amino-1-arylpropan-1,3-diols were prepared selectively through elaboration of trans-4-aryl-3-chloro-β-lactams. In addition, a number of 2-(azidomethyl)aziridines was converted into novel 2-[(1,2,3-triazol-1...

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Detalles Bibliográficos
Autores principales: D’hooghe, Matthias, Vandekerckhove, Stéphanie, Mollet, Karen, Vervisch, Karel, Dekeukeleire, Stijn, Lehoucq, Liesbeth, Lategan, Carmen, Smith, Peter J, Chibale, Kelly, De Kimpe, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252880/
https://www.ncbi.nlm.nih.gov/pubmed/22238554
http://dx.doi.org/10.3762/bjoc.7.205