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Whole Genome Characterization of the Mechanisms of Daptomycin Resistance in Clinical and Laboratory Derived Isolates of Staphylococcus aureus

BACKGROUND: Daptomycin remains one of our last-line anti-staphylococcal agents. This study aims to characterize the genetic evolution to daptomycin resistance in S. aureus. METHODS: Whole genome sequencing was performed on a unique collection of isogenic, clinical (21 strains) and laboratory (12 str...

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Detalles Bibliográficos
Autores principales: Peleg, Anton Y., Miyakis, Spiros, Ward, Doyle V., Earl, Ashlee M., Rubio, Aileen, Cameron, David R., Pillai, Satish, Moellering, Robert C., Eliopoulos, George M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253072/
https://www.ncbi.nlm.nih.gov/pubmed/22238576
http://dx.doi.org/10.1371/journal.pone.0028316