Mutational Analyses of the Influenza A Virus Polymerase Subunit PA Reveal Distinct Functions Related and Unrelated to RNA Polymerase Activity

Influenza A viral polymerase is a heterotrimeric complex that consists of PA, PB1, and PB2 subunits. We previously reported that a di-codon substitution mutation (G507A-R508A), denoted J10, in the C-terminal half of PA had no apparent effect on viral RNA synthesis but prevented infectious virus prod...

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Detalles Bibliográficos
Autores principales: Liang, Yuhong, Danzy, Shamika, Dao, Luan Danh, Parslow, Tristram G., Liang, Yuying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253111/
https://www.ncbi.nlm.nih.gov/pubmed/22238617
http://dx.doi.org/10.1371/journal.pone.0029485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253111/
https://www.ncbi.nlm.nih.gov/pubmed/22238617
http://dx.doi.org/10.1371/journal.pone.0029485

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