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Presenilin Is the Molecular Target of Acidic γ-Secretase Modulators in Living Cells
The intramembrane-cleaving protease γ-secretase catalyzes the last step in the generation of toxic amyloid-β (Aβ) peptides and is a principal therapeutic target in Alzheimer's disease. Both preclinical and clinical studies have demonstrated that inhibition of γ-secretase is associated with proh...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253113/ https://www.ncbi.nlm.nih.gov/pubmed/22238696 http://dx.doi.org/10.1371/journal.pone.0030484 |