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Presenilin Is the Molecular Target of Acidic γ-Secretase Modulators in Living Cells

The intramembrane-cleaving protease γ-secretase catalyzes the last step in the generation of toxic amyloid-β (Aβ) peptides and is a principal therapeutic target in Alzheimer's disease. Both preclinical and clinical studies have demonstrated that inhibition of γ-secretase is associated with proh...

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Detalles Bibliográficos
Autores principales:	Jumpertz, Thorsten, Rennhack, Andreas, Ness, Julia, Baches, Sandra, Pietrzik, Claus U., Bulic, Bruno, Weggen, Sascha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253113/ https://www.ncbi.nlm.nih.gov/pubmed/22238696 http://dx.doi.org/10.1371/journal.pone.0030484

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