Low levels of SIV infection in sooty mangabey central-memory CD4+ T-cells is associated with limited CCR5 expression

Naturally SIV-infected sooty mangabeys (SMs) do not progress to AIDS despite high-level virus replication. We previously showed that the fraction of CD4+CCR5+ T-cells is lower in SMs compared to humans and macaques. Here we found that, after in vitro stimulation, SM CD4+ T-cells fail to up-regulate...

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Detalles Bibliográficos
Autores principales: Paiardini, Mirko, Cervasi, Barbara, Reyes-Aviles, Elane, Micci, Luca, Ortiz, Alexandra M., Chahroudi, Ann, Vinton, Carol, Gordon, Shari N., Bosinger, Steven E., Francella, Nicholas, Hallberg, Paul L., Schlub, Timothy, Chan, Ming Liang, Riddick, Nadeene E., Collman, Ronald G., Apetrei, Cristian, Pandrea, Ivona, Else, James, Munch, Jan, Kirchhoff, Frank, Davenport, Miles P., Brenchley, Jason M., Silvestri, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253129/
https://www.ncbi.nlm.nih.gov/pubmed/21706028
http://dx.doi.org/10.1038/nm.2395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253129/
https://www.ncbi.nlm.nih.gov/pubmed/21706028
http://dx.doi.org/10.1038/nm.2395

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