Cargando…

Antiparallel EmrE exports drugs by exchanging between asymmetric structures

Small multidrug resistance (SMR) transporters provide an ideal system to study the minimal requirements for active transport. EmrE is an E. coli SMR transporter that exports a broad class of polyaromatic cation substrates, thus conferring resistance to drug compounds matching this chemical descripti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morrison, Emma A., DeKoster, Gregory T., Dutta, Supratik, Clarkson, Michael W., Vafabakhsh, Reza, Bahl, Arjun, Kern, Dorothee, Ha, Taekjip, Henzler-Wildman, Katherine A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253143/ https://www.ncbi.nlm.nih.gov/pubmed/22178925 http://dx.doi.org/10.1038/nature10703

Ejemplares similares

Asymmetric protonation of EmrE
por: Morrison, Emma A., et al.
Publicado: (2015)

Identification of an Alternating-Access Dynamics Mutant of EmrE with Impaired Transport
por: Wu, Chao, et al.
Publicado: (2019)

High-pH structure of EmrE reveals the mechanism of proton-coupled substrate transport
por: Shcherbakov, Alexander A., et al.
Publicado: (2022)

Red Blood Cell Invasion by Plasmodium vivax: Structural Basis for DBP Engagement of DARC
por: Batchelor, Joseph D., et al.
Publicado: (2014)

Structure and dynamics of the drug-bound bacterial transporter EmrE in lipid bilayers
por: Shcherbakov, Alexander A., et al.
Publicado: (2021)

Charge neutralization of the active site glutamates does not limit substrate binding and transport by small multidrug resistance transporter EmrE
por: Spreacker, Peyton J., et al.
Publicado: (2022)

The antiparallel loops in gal DNA
por: Lia, Giuseppe, et al.
Publicado: (2008)

Antiparallel Dynamic Covalent Chemistries
por: Matysiak, Bartosz M., et al.
Publicado: (2017)

Amyloid Evolution: Antiparallel Replaced by Parallel
por: Zanjani, Ali Asghar Hakami, et al.
Publicado: (2020)

Exchange rate volatility and manufacturing commodity exports in ASEAN-5: A symmetric and asymmetric approach
por: Handoyo, Rossanto Dwi, et al.
Publicado: (2023)

Highly coupled transport can be achieved in free-exchange transport models
por: Hussey, Grant A., et al.
Publicado: (2019)

Structural dynamics of potassium channel gating revealed by single molecule FRET
por: Wang, Shizhen, et al.
Publicado: (2015)

KAP1 is an antiparallel dimer with a functional asymmetry
por: Fonti, Giulia, et al.
Publicado: (2019)

Bimodular Antiparallel G-Quadruplex Nanoconstruct with Antiproliferative Activity
por: Antipova, Olga, et al.
Publicado: (2019)

EMR in Eye Units
por: Camburu, Georgiana, et al.
Publicado: (2020)

Lamin Filament Assembly Derived from the Atomic Structure of the Antiparallel Four-Helix Bundle
por: Ahn, Jinsook, et al.
Publicado: (2023)

Bacterial actin MreB forms antiparallel double filaments
por: van den Ent, Fusinita, et al.
Publicado: (2014)

Cutting antiparallel DNA strands in a single active site
por: Chen, Xuemin, et al.
Publicado: (2020)

Functional Characterization of the Internal Symmetry of MRAP2 Antiparallel Homodimer
por: Wang, Meng, et al.
Publicado: (2021)

A Chimeric DNA/RNA Antiparallel Quadruplex with Improved Stability
por: Boyle, Elaina P., et al.
Publicado: (2022)

The ‘Anchoring-EMR’ technique has already been described and named the ‘Tip-in EMR’ technique
por: Imai, Kenichiro, et al.
Publicado: (2020)

Combining structured and unstructured data in EMRs to create clinically-defined EMR-derived cohorts
por: Tam, Charmaine S., et al.
Publicado: (2021)

The impact of exchange rate volatility on Indonesia's top exports to the five main export markets
por: Sugiharti, Lilik, et al.
Publicado: (2020)

Implementation of an innovative, integrated electronic medical record (EMR) and public health information exchange for HIV/AIDS
por: Herwehe, Jane, et al.
Publicado: (2011)

Immunization registries in the EMR Era
por: Stevens, Lindsay A., et al.
Publicado: (2013)

Correction: Bacterial actin MreB forms antiparallel double filaments
por: van den Ent, Fusinita, et al.
Publicado: (2014)

Bidirectional biomimetic flow sensing with antiparallel and curved artificial hair sensors
por: Abels, Claudio, et al.
Publicado: (2019)

Topography-induced large-scale antiparallel collective migration in vascular endothelium
por: Leclech, Claire, et al.
Publicado: (2022)

Force-Triggered Atropisomerization of a Parallel Diarylethene to Its Antiparallel Diastereomers
por: Fu, Xuancheng, et al.
Publicado: (2023)

A Promiscuous DNA Packaging Machine from Bacteriophage T4
por: Zhang, Zhihong, et al.
Publicado: (2011)

EmrR-Dependent Upregulation of the Efflux Pump EmrCAB Contributes to Antibiotic Resistance in Chromobacterium violaceum
por: Barroso, Kelly C. M., et al.
Publicado: (2018)

Computer simulations reveal motor properties generating stable antiparallel microtubule interactions
por: Nédélec, François
Publicado: (2002)

Distinct roles for antiparallel microtubule pairing and overlap during early spindle assembly
por: Nazarova, Elena, et al.
Publicado: (2013)

Air-drying of cells enables visualization of antiparallel microtubule overlaps in the spindle midzone
por: Ifuji, Aya, et al.
Publicado: (2018)

Recognition Interface of the Thrombin Binding Aptamer Requires Antiparallel Topology of the Quadruplex Core
por: Svetlova, Julia, et al.
Publicado: (2021)

Effect of Kinesin-5 Tail Domain on Motor Dynamics for Antiparallel Microtubule Sliding
por: Liu, Yuying, et al.
Publicado: (2021)

Intermediate antiparallel beta structure in amyloid plaques revealed by infrared spectroscopic imaging
por: Holcombe, Brooke, et al.
Publicado: (2023)

An emerging consensus for the structure of EmrE
por: Korkhov, Vladimir M., et al.
Publicado: (2009)

EMR of large periampullary neuroendocrine tumor
por: Nelsen, Eric M., et al.
Publicado: (2017)

Stress-Electromagnetic Radiation (EMR) Numerical Model and EMR Evolution Law of Composite Coal-Rock under Load
por: Li, Xin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8opb2c4jvkhmg0s8mrk297lrjl