Resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells in a sirtuin 1-dependent manner

Resveratrol, a phytoalexin, reduced the viability of MH7A cells, a human rheumatoid arthritis synovial cell line. In the apoptosis assay, resveratrol increased TUNEL-positive cells and stimulated H2A.X phosphorylation. Resveratrol disrupted mitochondrial membrane potentials in MH7A cells and stimula...

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Detalles Bibliográficos
Autores principales: Nakayama, Hiroshi, Yaguchi, Takahiro, Yoshiya, Shinichi, Nishizaki, Tomoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253293/
https://www.ncbi.nlm.nih.gov/pubmed/20697895
http://dx.doi.org/10.1007/s00296-010-1598-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253293/
https://www.ncbi.nlm.nih.gov/pubmed/20697895
http://dx.doi.org/10.1007/s00296-010-1598-8

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