Two Brothers with Skewed Thiopurine Metabolism in Ulcerative Colitis Treated Successfully with Allopurinol and Mercaptopurine Dose Reduction

Thiopurine therapy effectively maintains remission in inflammatory bowel disease. However, many patients are unable to achieve optimum benefits from azathioprine or 6-mercaptopurine because of undesirable metabolism related to high thiopurine methyltransferase (TPMT) activity characterized by hepati...

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Detalles Bibliográficos
Autores principales: Hoentjen, Frank, Hanauer, Stephen B., de Boer, Nanne K., Rubin, David T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253335/
https://www.ncbi.nlm.nih.gov/pubmed/22147254
http://dx.doi.org/10.1007/s10620-011-1999-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253335/
https://www.ncbi.nlm.nih.gov/pubmed/22147254
http://dx.doi.org/10.1007/s10620-011-1999-x

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