Searching for DNA Lesions: Structural Evidence for Lower- and Higher-Affinity DNA Binding Conformations of Human Alkyladenine DNA Glycosylase

[Image: see text] To efficiently repair DNA, human alkyladenine DNA glycosylase (AAG) must search the million-fold excess of unmodified DNA bases to find a handful of DNA lesions. Such a search can be facilitated by the ability of glycosylases, like AAG, to interact with DNA using two affinities: a...

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Detalles Bibliográficos
Autores principales: Setser, Jeremy W., Lingaraju, Gondichatnahalli M., Davis, C. Ainsley, Samson, Leona D., Drennan, Catherine L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254189/
https://www.ncbi.nlm.nih.gov/pubmed/22148158
http://dx.doi.org/10.1021/bi201484k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254189/
https://www.ncbi.nlm.nih.gov/pubmed/22148158
http://dx.doi.org/10.1021/bi201484k

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