Novel structurally related compounds reactivate latent HIV-1 in a bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation

BACKGROUND: The latent reservoir of HIV-1 in resting memory CD4+ T cells is a major barrier to curing HIV-1 infection. Eradication strategies involve reactivation of this latent reservoir; however, agents that reactivate latent HIV-1 through non-specific T cell activation are toxic. METHODS: Using l...

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Detalles Bibliográficos
Autores principales: Xing, Sifei, Bhat, Shridhar, Shroff, Neeta S., Zhang, Hao, Lopez, Joseph A., Margolick, Joseph B., Liu, Jun O., Siliciano, Robert F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254198/
https://www.ncbi.nlm.nih.gov/pubmed/22160146
http://dx.doi.org/10.1093/jac/dkr496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254198/
https://www.ncbi.nlm.nih.gov/pubmed/22160146
http://dx.doi.org/10.1093/jac/dkr496

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