Cargando…

Novel structurally related compounds reactivate latent HIV-1 in a bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation

BACKGROUND: The latent reservoir of HIV-1 in resting memory CD4+ T cells is a major barrier to curing HIV-1 infection. Eradication strategies involve reactivation of this latent reservoir; however, agents that reactivate latent HIV-1 through non-specific T cell activation are toxic. METHODS: Using l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xing, Sifei, Bhat, Shridhar, Shroff, Neeta S., Zhang, Hao, Lopez, Joseph A., Margolick, Joseph B., Liu, Jun O., Siliciano, Robert F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254198/ https://www.ncbi.nlm.nih.gov/pubmed/22160146 http://dx.doi.org/10.1093/jac/dkr496

Ejemplares similares

An In-Depth Comparison of Latent HIV-1 Reactivation in Multiple Cell Model Systems and Resting CD4+ T Cells from Aviremic Patients
por: Spina, Celsa A., et al.
Publicado: (2013)

Efforts to eliminate the latent reservoir in resting CD4+ T cells: strategies for curing HIV-1 infection
por: Ho, Ya-Chi, et al.
Publicado: (2015)

Proliferation of latently infected CD4(+) T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics
por: Hosmane, Nina N., et al.
Publicado: (2017)

Scopoletin Reactivates Latent HIV-1 by Inducing NF-κB Expression without Global T Cell Activation
por: Zhu, Yuqi, et al.
Publicado: (2023)

Homeostatically Maintained Resting Naive CD4(+) T Cells Resist Latent HIV Reactivation
por: Tsunetsugu-Yokota, Yasuko, et al.
Publicado: (2016)

Latent Cytomegalovirus-Driven Recruitment of Activated CD4+ T Cells Promotes Virus Reactivation
por: Jackson, Sarah E., et al.
Publicado: (2021)

Reactivating latent HIV with PKC agonists induces resistance to apoptosis and is associated with phosphorylation and activation of BCL2
por: French, Andrea J., et al.
Publicado: (2020)

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations
por: Deng, Kai, et al.
Publicado: (2015)

Insufficient Evidence for Rare Activation of Latent HIV in the Absence of Reservoir-Reducing Interventions
por: Hill, Alison L., et al.
Publicado: (2016)

BCG Vaccination Prevents Reactivation of Latent Lymphatic Murine Tuberculosis Independently of CD4(+) T Cells
por: Sathkumara, Harindra D., et al.
Publicado: (2019)

1530. Reactivation of Latent HIV in CD4 T Cells Procured from Patients on ART by Autologous CD8 T cells or Fas Ligand
por: Leshin-Carmel, Daniel, et al.
Publicado: (2023)

A novel quantitative approach for measuring the reservoir of latent HIV-1 proviruses
por: Bruner, Katherine M., et al.
Publicado: (2019)

CD4(+) and CD8(+) T Cell Activation Are Associated with HIV DNA in Resting CD4(+) T Cells
por: Cockerham, Leslie R., et al.
Publicado: (2014)

HCMV Protein LUNA Is Required for Viral Reactivation from Latently Infected Primary CD14(+) Cells
por: Keyes, Lisa R., et al.
Publicado: (2012)

Lentiviral vectors transduce lung stem cells without disrupting plasticity
por: Cooney, Ashley L., et al.
Publicado: (2021)

Limits on Replenishment of the Resting CD4(+) T Cell Reservoir for HIV in Patients on HAART
por: Sedaghat, Ahmad R, et al.
Publicado: (2007)

Homeostatic Proliferation Fails to Efficiently Reactivate HIV-1 Latently Infected Central Memory CD4+ T Cells
por: Bosque, Alberto, et al.
Publicado: (2011)

Reactivation of latent HIV-1 in central memory CD4(+) T cells through TLR-1/2 stimulation
por: Novis, Camille L, et al.
Publicado: (2013)

Correction: HCMV Protein LUNA Is Required for Viral Reactivation from Latently Infected Primary CD14(+) Cells
por: Keyes, Lisa R., et al.
Publicado: (2013)

Differential CD4+ T-Cell Cytokine and Cytotoxic Responses Between Reactivation and Latent Phases of Herpes Zoster Infection
por: Jin, Wenjie, et al.
Publicado: (2023)

Primary CD8(+) T cells from elite suppressors effectively eliminate non-productively HIV-1 infected resting and activated CD4(+) T cells
por: Buckheit, Robert W, et al.
Publicado: (2013)

Rapid Quantification of the Latent Reservoir for HIV-1 Using a Viral Outgrowth Assay
por: Laird, Gregory M., et al.
Publicado: (2013)

The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells
por: Kaizuka, Yoshihisa, et al.
Publicado: (2009)

Designing and Interpreting Limiting Dilution Assays: General Principles and Applications to the Latent Reservoir for Human Immunodeficiency Virus-1
por: Rosenbloom, Daniel I. S., et al.
Publicado: (2015)

Tissue-specific control of latent CMV reactivation by regulatory T cells
por: Almanan, Maha, et al.
Publicado: (2017)

Mycobacterium tuberculosis reactivates latent HIV-1 in T cells in vitro
por: Larson, Erica C., et al.
Publicado: (2017)

An essential EBV latent antigen 3C binds Bcl6 for targeted degradation and cell proliferation
por: Pei, Yonggang, et al.
Publicado: (2017)

Clonal CD4+ T cells in the HIV-1 latent reservoir display a distinct gene profile upon reactivation
por: Cohn, Lillian B., et al.
Publicado: (2018)

Transcriptome profiles of latently- and reactivated HIV-1 infected primary CD4(+) T cells: A pooled data-analysis
por: Inderbitzin, Anne, et al.
Publicado: (2022)

The bromodomain and extraterminal domain inhibitor bromosporine synergistically reactivates latent HIV-1 in latently infected cells
por: Pan, Hanyu, et al.
Publicado: (2017)

CD137L and CD4 T cells limit BCL6‐expressing pre‐germinal center B cell expansion and BCL6‐driven B cell malignancy
por: Ding, Zhoujie, et al.
Publicado: (2022)

Tissue-Resident Memory-Like CD8(+) T Cells Exhibit Heterogeneous Characteristics in Tuberculous Pleural Effusion
por: Yu, Sifei, et al.
Publicado: (2021)

HIV Reactivation in Latently Infected Cells with Virological Synapse-Like Cell Contact
por: Okutomi, Toshiki, et al.
Publicado: (2020)

Suppression of Signal Transducer and Activator of Transcription 3–Dependent B Lymphocyte Terminal Differentiation by Bcl-6
por: Reljic, Rajko, et al.
Publicado: (2000)

Measuring replication competent HIV-1: advances and challenges in defining the latent reservoir
por: Wang, Zheng, et al.
Publicado: (2018)

Activation and lysis of human CD4 cells latently infected with HIV-1
por: Pegu, Amarendra, et al.
Publicado: (2015)

Signaling through polymerization and degradation: Analysis and simulations of T cell activation mediated by Bcl10
por: Campanello, Leonard, et al.
Publicado: (2021)

Visualization of HIV-1 RNA Transcription from Integrated HIV-1 DNA in Reactivated Latently Infected Cells
por: Ukah, Obiaara B., et al.
Publicado: (2018)

Nitric Oxide Induces Cell Death by Regulating Anti-Apoptotic BCL-2 Family Members
por: Snyder, Colleen M., et al.
Publicado: (2009)

Chronic simian immunodeficiency virus infection is associated with contrasting phenotypes of dysfunctional Bcl6(+) germinal center B cells or Bcl6(−)Bcl2(+) non‐germinal center B cells
por: Onabajo, Olusegun O., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_1a79o415jaqud96htdei6itfrc