Modeling of Molecular Interaction between Apoptin, BCR-Abl and CrkL - An Alternative Approach to Conventional Rational Drug Design

In this study we have calculated a 3D structure of apoptin and through modeling and docking approaches, we show its interaction with Bcr-Abl oncoprotein and its downstream signaling components, following which we confirm some of the newly-found interactions by biochemical methods. Bcr-Abl oncoprotei...

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Detalles Bibliográficos
Autores principales: Panigrahi, Soumya, Stetefeld, Jörg, Jangamreddy, Jaganmohan R., Mandal, Soma, Mandal, Sanat K., Los, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254606/
https://www.ncbi.nlm.nih.gov/pubmed/22253690
http://dx.doi.org/10.1371/journal.pone.0028395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254606/
https://www.ncbi.nlm.nih.gov/pubmed/22253690
http://dx.doi.org/10.1371/journal.pone.0028395

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