Hedgehog-Regulated Ubiquitination Controls Smoothened Trafficking and Cell Surface Expression in Drosophila

Hedgehog transduces signal by promoting cell surface expression of the seven-transmembrane protein Smoothened (Smo) in Drosophila, but the underlying mechanism remains unknown. Here we demonstrate that Smo is downregulated by ubiquitin-mediated endocytosis and degradation, and that Hh increases Smo...

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Detalles Bibliográficos
Autores principales: Li, Shuang, Chen, Yongbin, Shi, Qing, Yue, Tao, Wang, Bing, Jiang, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254653/
https://www.ncbi.nlm.nih.gov/pubmed/22253574
http://dx.doi.org/10.1371/journal.pbio.1001239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254653/
https://www.ncbi.nlm.nih.gov/pubmed/22253574
http://dx.doi.org/10.1371/journal.pbio.1001239

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