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Hedgehog-Regulated Ubiquitination Controls Smoothened Trafficking and Cell Surface Expression in Drosophila
Hedgehog transduces signal by promoting cell surface expression of the seven-transmembrane protein Smoothened (Smo) in Drosophila, but the underlying mechanism remains unknown. Here we demonstrate that Smo is downregulated by ubiquitin-mediated endocytosis and degradation, and that Hh increases Smo...
Autores principales: | Li, Shuang, Chen, Yongbin, Shi, Qing, Yue, Tao, Wang, Bing, Jiang, Jin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254653/ https://www.ncbi.nlm.nih.gov/pubmed/22253574 http://dx.doi.org/10.1371/journal.pbio.1001239 |
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