USP8 Promotes Smoothened Signaling by Preventing Its Ubiquitination and Changing Its Subcellular Localization

The seven transmembrane protein Smoothened (Smo) is a critical component of the Hedgehog (Hh) signaling pathway and is regulated by phosphorylation, dimerization, and cell-surface accumulation upon Hh stimulation. However, it is not clear how Hh regulates Smo accumulation on the cell surface or how...

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Detalles Bibliográficos
Autores principales: Xia, Ruohan, Jia, Hongge, Fan, Junkai, Liu, Yajuan, Jia, Jianhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254663/
https://www.ncbi.nlm.nih.gov/pubmed/22253573
http://dx.doi.org/10.1371/journal.pbio.1001238

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254663/
https://www.ncbi.nlm.nih.gov/pubmed/22253573
http://dx.doi.org/10.1371/journal.pbio.1001238

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