Disease Progression in MRL/lpr Lupus-Prone Mice Is Reduced by NCS 613, a Specific Cyclic Nucleotide Phosphodiesterase Type 4 (PDE4) Inhibitor

Systemic lupus erythematosus is a polymorphic and multigenic inflammatory autoimmune disease. Cyclic AMP (cAMP) modulates inflammation and the inhibition of cyclic nucleotide phosphodiesterase type 4 (PDE4), which specifically hydrolyzes cAMP, inhibits TNFα secretion. This study was aimed at investi...

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Detalles Bibliográficos
Autores principales: Keravis, Thérèse, Monneaux, Fanny, Yougbaré, Issaka, Gazi, Lucien, Bourguignon, Jean-Jacques, Muller, Sylviane, Lugnier, Claire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256138/
https://www.ncbi.nlm.nih.gov/pubmed/22247763
http://dx.doi.org/10.1371/journal.pone.0028899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256138/
https://www.ncbi.nlm.nih.gov/pubmed/22247763
http://dx.doi.org/10.1371/journal.pone.0028899

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