Identification of Simple Compounds with Microtubule-Binding Activity That Inhibit Cancer Cell Growth with High Potency

[Image: see text] We analyzed more than 1 million small molecules with the goal of finding simple synthetic compounds that potently inhibit cancer cell growth. We identified three such compounds with unknown mechanisms of action. Subsequent studies revealed that all three of these small molecules ta...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Wan Seok, Shimada, Kenichi, Delva, Darnelle, Patel, Milesh, Ode, Egberamwen, Skouta, Rachid, Stockwell, Brent R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256933/
https://www.ncbi.nlm.nih.gov/pubmed/22247791
http://dx.doi.org/10.1021/ml200195s
_version_ 1782221077400780800
author Yang, Wan Seok
Shimada, Kenichi
Delva, Darnelle
Patel, Milesh
Ode, Egberamwen
Skouta, Rachid
Stockwell, Brent R.
author_facet Yang, Wan Seok
Shimada, Kenichi
Delva, Darnelle
Patel, Milesh
Ode, Egberamwen
Skouta, Rachid
Stockwell, Brent R.
author_sort Yang, Wan Seok
collection PubMed
description [Image: see text] We analyzed more than 1 million small molecules with the goal of finding simple synthetic compounds that potently inhibit cancer cell growth. We identified three such compounds with unknown mechanisms of action. Subsequent studies revealed that all three of these small molecules target microtubules. These three scaffolds can serve as templates for developing new microtubule-targeted agents, overcoming the limits of existing microtubule-inhibiting drugs derived from complex natural products.
format Online
Article
Text
id pubmed-3256933
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-32569332012-01-12 Identification of Simple Compounds with Microtubule-Binding Activity That Inhibit Cancer Cell Growth with High Potency Yang, Wan Seok Shimada, Kenichi Delva, Darnelle Patel, Milesh Ode, Egberamwen Skouta, Rachid Stockwell, Brent R. ACS Med Chem Lett [Image: see text] We analyzed more than 1 million small molecules with the goal of finding simple synthetic compounds that potently inhibit cancer cell growth. We identified three such compounds with unknown mechanisms of action. Subsequent studies revealed that all three of these small molecules target microtubules. These three scaffolds can serve as templates for developing new microtubule-targeted agents, overcoming the limits of existing microtubule-inhibiting drugs derived from complex natural products. American Chemical Society 2011-10-31 /pmc/articles/PMC3256933/ /pubmed/22247791 http://dx.doi.org/10.1021/ml200195s Text en Copyright © 2011 American Chemical Society Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html)
spellingShingle Yang, Wan Seok
Shimada, Kenichi
Delva, Darnelle
Patel, Milesh
Ode, Egberamwen
Skouta, Rachid
Stockwell, Brent R.
Identification of Simple Compounds with Microtubule-Binding Activity That Inhibit Cancer Cell Growth with High Potency
title Identification of Simple Compounds with Microtubule-Binding Activity That Inhibit Cancer Cell Growth with High Potency
title_full Identification of Simple Compounds with Microtubule-Binding Activity That Inhibit Cancer Cell Growth with High Potency
title_fullStr Identification of Simple Compounds with Microtubule-Binding Activity That Inhibit Cancer Cell Growth with High Potency
title_full_unstemmed Identification of Simple Compounds with Microtubule-Binding Activity That Inhibit Cancer Cell Growth with High Potency
title_short Identification of Simple Compounds with Microtubule-Binding Activity That Inhibit Cancer Cell Growth with High Potency
title_sort identification of simple compounds with microtubule-binding activity that inhibit cancer cell growth with high potency
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256933/
https://www.ncbi.nlm.nih.gov/pubmed/22247791
http://dx.doi.org/10.1021/ml200195s
work_keys_str_mv AT yangwanseok identificationofsimplecompoundswithmicrotubulebindingactivitythatinhibitcancercellgrowthwithhighpotency
AT shimadakenichi identificationofsimplecompoundswithmicrotubulebindingactivitythatinhibitcancercellgrowthwithhighpotency
AT delvadarnelle identificationofsimplecompoundswithmicrotubulebindingactivitythatinhibitcancercellgrowthwithhighpotency
AT patelmilesh identificationofsimplecompoundswithmicrotubulebindingactivitythatinhibitcancercellgrowthwithhighpotency
AT odeegberamwen identificationofsimplecompoundswithmicrotubulebindingactivitythatinhibitcancercellgrowthwithhighpotency
AT skoutarachid identificationofsimplecompoundswithmicrotubulebindingactivitythatinhibitcancercellgrowthwithhighpotency
AT stockwellbrentr identificationofsimplecompoundswithmicrotubulebindingactivitythatinhibitcancercellgrowthwithhighpotency

Ejemplares similares