Steroidomimetic Tetrahydroisoquinolines for the Design of New Microtubule Disruptors

[Image: see text] Structure–activity relationship translation offers an expeditious means for discovery of new active series. This approach was applied to discover tetrahydroisoquinoline (THIQ)-based steroidomimetic microtubule disruptors. The two A-ring elements of a three-point steroidal pharmacop...

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Detalles Bibliográficos
Autores principales: Leese, Mathew P., Jourdan, Fabrice, Dohle, Wolfgang, Kimberley, Meriel R., Thomas, Mark P., Bai, Ruoli, Hamel, Ernest, Ferrandis, Eric, Potter, Barry V. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256937/
https://www.ncbi.nlm.nih.gov/pubmed/22247790
http://dx.doi.org/10.1021/ml200232c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256937/
https://www.ncbi.nlm.nih.gov/pubmed/22247790
http://dx.doi.org/10.1021/ml200232c

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