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Steroidomimetic Tetrahydroisoquinolines for the Design of New Microtubule Disruptors

[Image: see text] Structure–activity relationship translation offers an expeditious means for discovery of new active series. This approach was applied to discover tetrahydroisoquinoline (THIQ)-based steroidomimetic microtubule disruptors. The two A-ring elements of a three-point steroidal pharmacop...

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Detalles Bibliográficos
Autores principales:	Leese, Mathew P., Jourdan, Fabrice, Dohle, Wolfgang, Kimberley, Meriel R., Thomas, Mark P., Bai, Ruoli, Hamel, Ernest, Ferrandis, Eric, Potter, Barry V. L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2011
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256937/ https://www.ncbi.nlm.nih.gov/pubmed/22247790 http://dx.doi.org/10.1021/ml200232c

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