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Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity
Ecotropic viral integration site 1 (Evi1), a transcription factor of the SET/PR domain protein family, is essential for the maintenance of hematopoietic stem cells (HSCs) in mice and is overexpressed in several myeloid malignancies. Here, we generate reporter mice in which an internal ribosome entry...
Autores principales: | Kataoka, Keisuke, Sato, Tomohiko, Yoshimi, Akihide, Goyama, Susumu, Tsuruta, Takako, Kobayashi, Hiroshi, Shimabe, Munetake, Arai, Shunya, Nakagawa, Masahiro, Imai, Yoichi, Kumano, Keiki, Kumagai, Katsuyoshi, Kubota, Naoto, Kadowaki, Takashi, Kurokawa, Mineo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256960/ https://www.ncbi.nlm.nih.gov/pubmed/22084405 http://dx.doi.org/10.1084/jem.20110447 |
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